Gene Cluster Analysis of Marine Bacteria Seeking for Natural Anticancer Products
نویسندگان
چکیده
Background: In the past decade, metabolites of marine microorganisms have been increasingly used for their various biological activities. An intense effort has dedicated to assessing therapeutic efficacy natural products and obtained from bacteria in cancer therapy. Fast reliable analytical bacterial genome sequencing provides specialized bioinformatic tools identify potential gene clusters obtaining secondary metabolites. Objectives: This study aimed analyze sequences recognize bioactive compounds with anti-cancer properties. Methods: Marine genomic registered National Center Biotechnology Information (NCBI) database were this study. The was analyzed proteins, tRNAs, rRNAs GenBank entries by Feature Extract 1.2L Server. Anti-SMASH webserver analysis unique genome, available NCBI database. Results: A number species, including Salinispora arenicola, tropica, Crocosphaera watsonii, Blastopirellula marina encoded belonging polyketide nonribosomal peptide (NRP) families, showing Among species described, S. tropica arenicola are richer genes encoding NRP antitumor Conclusions: an excellent exceptional source compounds. silico provided opportunity evaluate known products. Like chemical engineering approaches pharmaceutical application useful clinical evaluation treatment.
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ژورنال
عنوان ژورنال: Jundishapur Journal of Natural Pharmaceutical Products
سال: 2021
ISSN: ['1735-7780', '2228-7876']
DOI: https://doi.org/10.5812/jjnpp.104665